1、despite介词，“不管、尽管、任凭”，后面可跟名词、动词ing或句子，如： He came to the meeting despite his serious illness. 尽管病的很重，他还是来参加了会议。

2、 2、Despite wanting to see him again, she refused to reply to his letters. 尽管很想再次见见他，她还是拒绝答复他的信。

3、 3、Despite what others say, I think he is a good boy. 不管别人说什么，我还是认为他是个好男孩。

4、 也可以用词组in despite of，但常用in spite of。